The Amino Terminus of Smads Permits Transcriptional Specificity
نویسندگان
چکیده
منابع مشابه
Transcriptional Control by the SMADs.
The transforming growth factor-β (TGF-β) family of ligands elicit their biological effects by initiating new programs of gene expression. The best understood signal transducers for these ligands are the SMADs, which essentially act as transcription factors that are activated in the cytoplasm and then accumulate in the nucleus in response to ligand induction where they bind to enhancer/promoter ...
متن کاملLinking Smads and transcriptional activation.
TGF-beta1 (transforming growth factor-beta1) is the prototypical member of a large family of pleiotropic cytokines that regulate diverse biological processes during development and adult tissue homoeostasis. TGF-beta signals via membrane bound serine/threonine kinase receptors which transmit their signals via the intracellular signalling molecules Smad2, Smad3 and Smad4. These Smads contain con...
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Programs in Cell Biology and Developmental Biology ence with Smad signaling inhibits the ligand-induced response, Smads are considered as effectors for the ligand-induced transcriptional responses. Recent progress provides insight into the mechanisms through which Smads regulate transcription and explains the sequence heterogeneity of the TGF-/activin-respon-Smads are a class of proteins that ...
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The transcriptional activator Ste12p is required for the expression of genes induced by mating pheromone in the yeast Saccharomyces cerevisiae. We identified mutations in the amino-terminal DNA-binding domain of Ste12p that lead to constitutively high-level transcription of pheromone-induced genes. The behaviour of these mutant proteins is consistent with an enhanced DNA-binding ability. Cells ...
متن کاملGlobal and specific transcriptional repression by the histone H3 amino terminus in yeast.
The yeast CHA1 promoter is activated in the presence of serine or threonine. Activation requires the Cha4p activator, and it results in perturbation of a nucleosome that incorporates the TATA element under noninducing conditions. We show that in yeast lacking the amino terminus of histone H3, the promoter is constitutively active and the chromatin is concomitantly perturbed. This derepression o...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2001
ISSN: 0012-1606
DOI: 10.1006/dbio.2000.0111